OSTEOPOROSIS: HORMONE REPLACEMENT AND OTHER THERAPY
Апрель 1st, 2009While research continues on osteoporosis, it is not possible to say whether it is due solely to calcium malnutrition, lack of exercise or hormone deficiency, but probably it will be found to be an interplay of all three factors. Each woman is unique with her individual needs and concerns.
There has been a great deal of confusion and controversy concerning hormone therapy to prevent osteoporosis, with research still being carried out and new aspects continually being discovered.
The term ‘Oestrogen Replacement Therapy’ was formerly used, but since it was realized that therapy frequently involves more than oestrogen, the terminology ‘Hormone Replacement Therapy’ (HRT) is preferred by physicians.
If you are at high risk of developing brittle bones in later years, with many of the negative factors that cannot be eliminated, when calcium absorption may be insufficient and exercise impossible, discuss hormone replacement therapy with your physician. HRT is available under the National Health Service, and may be prescribed by your GP or NHS clinic. Your doctor will probably strongly recommend hormone replacement therapy if:
your menstrual periods stopped at an early age; or
you have had surgery to remove your ovaries, effecting a
surgical menopause; or
• you have had bone-mass tests at regular intervals that reveal
an increasing porosity and risk of fracturing.
Just what is HRT, what are the good points and what are the bad? The ‘balance sheet’ of hormones for bone formation, with oestrogen and progesterone from the ovaries on the positive side. It’s natural for ovaries to start producing hormones at puberty and wind down production at menopause. It’s a misconception that you produce no more natural oestrogen and need full replacement of this hormone at that time. In many menopausal women, ovaries still produce oestrogen, but in insufficient amounts to menstruate. When your ovaries stop making oestrogen, you are not completely lacking this hormone from other sources in your body. Oestrogens come
from the adrenal cortex in the adrenal gland (precursors of \ oestrogens);
indirectly from the body’s fat cells which convert androgens to oestrogens; and
from your ovaries (unless you have had them surgically removed), continuing to manufacture small quantities of androgens which are converted to oestrogens.
While it is true that the quantity of oestrogen drops, the big questions are whether this deficiency needs to be replaced, and if such replacement is safe.
It is important to ask probing questions of your physician if hormone replacement therapy is suggested, so you are aware of all the facts to make an informed decision. Know both sides of the issue and get a second opinion from another physician before reaching any conclusions. A decision made now may need reevaluating years hence if you experience severe deterioration in bone mass or if particular drugs are later produced that may be suitable for you.
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Метки: Healthy bones